Kirk J Ziegler

Advanced Chemical and Biological Processes Laboratory

The Department of Chemical Engineering has spent approximately $180,000 to develop a new laboratory course for graduate students.

This 3-credit, 4-hour lab course is specifically offered to master graduate students who want to have a basic training in the chemical and bioprocessing engineering discipline. The course aims to expand the students’ ability in hands-on experiments. The overall goal is to teach students to gain advanced polymer, chemical and bio-based processing techniques. After accomplishing the required work, students are expected to have basic concepts of several fundamental technical skills and have an overall understanding in this field.

Syllabus

Instructors/Teaching Assistants for Each Module

Module	Module Location	Instructor	Teaching Assistant
Safety & Ethics	CHE 237	Mark Orazem Oscar Crisalle
M-M Kinetics DNA Fingerprinting Polymerase Chain Reaction (PCR)	CHE 220	Tanmay Lele Yiider Tseng	Shenhsiu Hung Yuan Li
Polymer Extrusion	CHE 300A	Chang-Won Park	Akshay Vargantiwar
Hydrogel Formation Drug Release	CHE 220	Anuj Chauhan	Lokendrakumar Bengani Vincent Hsu
Spin-coating Polymer Films	CHE 220	Peng Jjiang Jason Butler	Yin Fang
Fluidized Bed	CHE 300A	Kirk Ziegler	Lingzhi Liao
Ammonia Absorption	CHE 300A	Oscar Crisalle Lewis Johns	Shyam Mudiraj
Heat Exchanger	CHE 300	Dmitry Kopelevich	Jai Kant
Pump System	CHE 300A	Dmitry Kopelevich	Tarun Narra

Module Descriptions and Objectives

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Michaelis-Menten Kinetics
Objectives	Understand the controlling factors of enzyme’s reaction rate Evaluate effects of controlling factors on the activity and reaction rate for biofuel production Analyze experiment results and fit data using Michaelis-Menten kinetics mode
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DNA Fingerprinting
Objectives	Understand and conduct enzyme digestion on DNA Understand and conduct DNA fragment separation using electrophoresis Introduce how DNA fingerprinting meets real life (Crime scene)
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Polymerase Chain Reaction (PCR)
Objectives	Understand the principle of polymerase chain reaction (PCR) and its application Conduct real-time PCR and operate a real time PCR thermocycler Match PCR results with the prediction by electrophoresis
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Polymer Extrusion
Objectives	Determine material flow rates of viscoelastic fluids at different screw speeds Determine dependence of extruded dimensions on process variables Use transport equations to predict extruded dimensions
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Hydrogel Formation
Objectives	Fabricate hydrogels through free-radical polymerization Measure ion permeability Use transport equations to predict behavior
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Drug Release
Objectives	Measure concentrations with UV-vis spectroscopy Measure drug release from hydrogels Use transport equations to understand release dynamics
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Spin-coating Polymer Films
Objectives	Investigate the effects of the important parameters of spin-coating processes Understand the basic concepts of shear thinning Use optical interference to measure film thickness
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Fluidized Bed
Objectives	Investigate the effects of process parameters on minimum fluidization velocity Understand the role that particle shape has on fluid flow and fluidization characteristics Use Ergun equation to predict fluidization behavior
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Ammonia Absorption
Objectives	Characterize the mass transfer coefficient for absorption when the gas side resistance dominates Characterize flooding conditions Determine hold-up time and time to reach steady state
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Heat Exchanger
Objectives	Investigate effects of control parameters and heat exchanger configuration on the heat transfer rate and overall heat transfer coefficient Investigate correlation between fluid flow characteristics and heat transfer Use transport equations to predict behavior
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Pump System
Objectives	Understand pump performance curves and sizing Understand pump configurations Use process control to control desired characteristics
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Poster Presentations

Finalized Poster Schedule for Spring 2013

ECH 6905L